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DeCS
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Descriptor English:
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Neurofilament Proteins
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Descriptor Spanish:
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Proteínas de Neurofilamentos
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Descriptor Portuguese:
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Proteínas de Neurofilamentos
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Synonyms English:
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Heavy Neurofilament Protein
Neurofilament Triplet Proteins
Neurofilament Protein, Heavy
Protein, Heavy Neurofilament
Proteins, Neurofilament
Proteins, Neurofilament Triplet
Triplet Proteins, Neurofilament
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Tree Number:
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D05.750.078.593.630
D12.776.220.475.630
D12.776.631.630
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Definition English:
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Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302) |
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Indexing Annotation English:
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/biosyn /physiol permitted
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History Note English:
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92; was NEUROFILAMENT PROTEINS (NM) 1977-91
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Allowable Qualifiers English:
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Record Number:
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29931
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Unique Identifier:
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D016900
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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